Drug Discovery & Drug Delivery

  • Synthesis of concise and diversity-oriented libraries (for target or phenotypic cell screenings)
  • Synthesis of nanodelivery systems
  • Synthesis of prodrugs
  • Development new green and sustainable reactions
  • Lead discovery and lead optimization
  • Structure-activity relationships (SAR)
  • Structure-property-activity relationships (SPAR)
  • Structure-property-toxicity relationships (SPTR)
  • Evaluation of drug-like properties (theoretical)

Biological screening assays

  • Cellular and non-cellular antioxidant assays
  • Enzymatic assays
  • Cytotoxicity
  • Metabolism and transport

In vitro evaluation of ADMET properties

  • Aqueous solubility
  • Liposolubility (LogD / LogP)
  • Chemical stability
  • Plasma stability
  • Plasma protein binding
  • Plasma microsomal stability
  • Dissociation constants (pKa)
  • Stability in simulated gastric/intestinal fluid
  • Non-cellular (Parallel Artificial Membrane Permeability Assay) and cellular permeability

Analytical chemistry

  • Evaluation of drug-drug and drug-metabolite interactions
  • Development of new (bio)analytical methodologies
  • Redox mechanisms
  • In vitro metabolite profiling and identification